851178-97-7

Basic information

• Product Name: 4-Chloro-3,5-difluoropyridine
• Synonyms: 4-Chloro-3,5-difluoropyridine
• CAS NO: 851178-97-7
• Molecular Formula: C₅H₂ClF₂N
• Molecular Weight: 149.5258864
• Mol File: 851178-97-7.mol

Chemical Properties

• Boiling Point: 124.065°C at 760 mmHg
• Flash Point: 28.834°C
• Appearance: /
• Density: 1.451g/cm³
• Vapor Pressure: 15.648mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-Chloro-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3,5-difluoropyridine(851178-97-7)
• EPA Substance Registry System: 4-Chloro-3,5-difluoropyridine(851178-97-7)

Safety Data

• Hazardous Substances Data: 851178-97-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-3,5-difluoropyridine is utilized as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-3,5-difluoropyridine serves as a key intermediate in the production of pesticides and other agrochemicals, enhancing crop protection and yield.
Used in Specialty Chemicals Production:
4-Chloro-3,5-difluoropyridine is employed in the manufacturing of dyes, pigments, and other specialty chemicals, providing a wide range of applications across different industries.
Used in Organic Compounds Synthesis:
As a versatile intermediate, 4-Chloro-3,5-difluoropyridine is used in the synthesis of various organic compounds, expanding its utility in chemical research and development.

InChI:InChI=1/C5H2ClF2N/c6-5-3(7)1-9-2-4(5)8/h1-2H

Upstream product

• 67-72-1 hexachloroethane 
• 71902-33-5 3,5-difluoropyridine 
• 76469-41-5 2,3,5‐trifluoropyridine 
• 700-16-3 Pentafluoropyridine 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 851179-05-0 3,5,6-trifluoro-2-hydrazinopyridine 
• 851179-06-1 3,5-difluoro-2-hydrazinylpyridine 

Downstream Products

• 67815-54-7 3,4,5-trifluoropyridine 
• 1370287-20-9 N'-(3,5-difluoropyridin-4-yl)-3-phenylpropanehydrazide 

Relevant articles and documents

Synthesis method of 3-fluoro-4-halo-5-methoxypyridine

The invention provides a synthesis method of 3-fluoro-4-halo-5-methoxypyridine, and belongs to the field of organic chemical synthesis. The method comprises the following steps: taking 3,5-difluoropyridine as a raw material, sequentially adding n-butyllithium and a halogenating reagent, carrying out a halogenation reaction, and carrying out post-treatment to obtain an intermediate 4-halo-3,5-difluoropyridine; and dissolving the intermediate in methanol, adding sodium methoxide, carrying out a methoxylation reaction, and carrying out post-treatment and column chromatography to obtain the targetproduct 3-fluoro-4-halo-5-methoxypyridine. The method has the advantages of simple process route, few byproducts, high purity, high yield and high additional values.

Removal of fluorine from and introduction of fluorine into polyhalopyridines: An exercise in nucleophilic hetarenic substitution

Starting from six industrially available fluorinated pyridines, an expedient access to all three tetrafluoropyridines (2-4), all six trifluoropyridines (5-10), and the five non-commercial difluoropyridines (11-14 and 16) was developed. The methods employed for the selective removal of fluorine from polyfluoropyridines were the reduction by metals or complex hydrides and the site-selective replacement by hydrazine followed by dehydrogenation-dediazotation or dehydrochlorination-dediazotation. To introduce an extra fluorine atom, a suitable precursor was metalated and chlorinated before being subjected to a chlorine/ fluorine displacement process.