851178-97-7

Basic information

• Product Name: 4-Chloro-3,5-difluoropyridine
• Synonyms: 4-Chloro-3,5-difluoropyridine
• CAS NO: 851178-97-7
• Molecular Formula: C₅H₂ClF₂N
• Molecular Weight: 149.5258864
• Mol File: 851178-97-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 124.065°C at 760 mmHg
• Flash Point: 28.834°C
• Appearance: /
• Density: 1.451g/cm³
• Vapor Pressure: 15.648mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-Chloro-3,5-difluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3,5-difluoropyridine(851178-97-7)
• EPA Substance Registry System: 4-Chloro-3,5-difluoropyridine(851178-97-7)

Safety Data

• Hazardous Substances Data: 851178-97-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-3,5-difluoropyridine is a chemical compound with the molecular formula C5H2ClF2N. It is a member of the pyridine family of compounds and has a chlorine atom at the 4 position and two fluorine atoms at the 3 and 5 positions on the pyridine ring. 4-Chloro-3,5-difluoropyridine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of dyes, pigments, and other specialty chemicals. 4-Chloro-3,5-difluoropyridine is a colorless liquid with a strong odor, and it is flammable and can be toxic if ingested or inhaled, so it should be handled and stored with care.

InChI:InChI=1/C5H2ClF2N/c6-5-3(7)1-9-2-4(5)8/h1-2H

Upstream product

• 67-72-1 hexachloroethane 
• 71902-33-5 3,5-difluoropyridine 
• 76469-41-5 2,3,5‐trifluoropyridine 
• 700-16-3 Pentafluoropyridine 
• 2875-18-5 2,3,5,6-tetrafluoropyridine 
• 851179-05-0 3,5,6-trifluoro-2-hydrazinopyridine 
• 851179-06-1 3,5-difluoro-2-hydrazinylpyridine 

Downstream Products

• 1370287-20-9 N'-(3,5-difluoropyridin-4-yl)-3-phenylpropanehydrazide 
• 67815-54-7 3,4,5-trifluoropyridine 

Relevant articles and documents

Synthesis method of 3-fluoro-4-halo-5-methoxypyridine

The invention provides a synthesis method of 3-fluoro-4-halo-5-methoxypyridine, and belongs to the field of organic chemical synthesis. The method comprises the following steps: taking 3,5-difluoropyridine as a raw material, sequentially adding n-butyllithium and a halogenating reagent, carrying out a halogenation reaction, and carrying out post-treatment to obtain an intermediate 4-halo-3,5-difluoropyridine; and dissolving the intermediate in methanol, adding sodium methoxide, carrying out a methoxylation reaction, and carrying out post-treatment and column chromatography to obtain the targetproduct 3-fluoro-4-halo-5-methoxypyridine. The method has the advantages of simple process route, few byproducts, high purity, high yield and high additional values.