851211-49-9Relevant academic research and scientific papers
One-pot Sonogashira coupling, hydroamination of alkyne and intramolecular C–H arylation reactions toward the synthesis of indole-fused benzosultams
Debnath, Sudarshan,Mondal, Shovan
supporting information, p. 2260 - 2263 (2018/05/23)
A one-pot Sonogashira coupling, hydroamination of alkyne and C–H arylation reactions for the synthesis of indole-fused benzosultams are described. This method allows access to a variety of indole-fused seven membered benzosultams in good to excellent yiel
A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands
Lanter, James C.,Fiordeliso, James J.,Allan, George F.,Musto, Amy,Hahn, Do Won,Sui, Zhihua
, p. 5646 - 5649 (2007/10/03)
Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.
NOVEL MCH RECEPTOR ANTAGONISTS
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Page/Page column 63, (2010/02/11)
The present invention relates to a melanin concentrating hormone antagonist compound of formula I: or a pharmaceutically acceptable salt thereof, useful for the treamtment useful fog treating Type H diabetes and/or obesity.
