851264-61-4

Basic information

• Product Name: 1-(2-chlorophenyl)piperidine-4-carboxylic acid
• Synonyms: 1-(2-chlorophenyl)piperidine-4-carboxylic acid
• CAS NO: 851264-61-4
• Molecular Formula: C12H14ClNO2
• Molecular Weight: 239.69806
• Mol File: 851264-61-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-chlorophenyl)piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorophenyl)piperidine-4-carboxylic acid(851264-61-4)
• EPA Substance Registry System: 1-(2-chlorophenyl)piperidine-4-carboxylic acid(851264-61-4)

Safety Data

• Hazardous Substances Data: 851264-61-4(Hazardous Substances Data)

Upstream product

• 2971-79-1 isonipecotic acid methyl ester 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 888038-30-0 1-(2-Chloro-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-amide 

Relevant articles and documents

Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease

We describe a series of potent and highly selective small-molecule MALT1 inhibitors, optimized from a High-Throughput Screening hit. Advanced analogues such as compound 40 show high potency (IC50: 0.01 μM) in a biochemical assay measuring MALT1 enzymatic activity, as well as in cellular assays: Jurkat T cell activation (0.05 μM) and IL6/10 secretion (IC50: 0.10/0.06 μM) in the TMD8 B-cell lymphoma line. Compound 40 also inhibited cleavage of the MALT1 substrate RelB (IC50: 0.10 μM). Mechanistic enzymology results suggest that these compounds bind to the known allosteric site of the protease.

4-Piperidinecarboxamide modulators of vanilloid VR1 receptor

This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.