851314-95-9

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 851314-92-6 2-(2-chloro-1,1-dimethylethyl)-4-fluoro-1-methoxybenzene 
• 566920-34-1 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid ethyl ester 
• 217196-31-1 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid 
• 851314-94-8 (αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester 
• 851314-93-7 4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester 

Downstream Products

• 851314-96-0 (R)-4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-trifluoromethylpentane-1,2-diol 
• 851314-97-1 (2R)-2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)-oxirane 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

The present invention provides compounds of formula (I): pharmaceutical compositions comprising the compounds and the use of the compounds for the manufacture of a medicament, particularly for the treatment of inflammation and/or allergic conditions.

Practical stereoselective synthesis of an α-trifluoromethyl-α- alkyl epoxide via a diastereoselective trifluoromethylation reaction

A practical stereoselective synthesis is reported for an α-trifluoromethyl-α-alkyl epoxide (1), which is an important pharmaceutical intermediate. The key step involves a chiral auxiliary-controlled asymmetric trifluoromethylation reaction for the introdu