851386-40-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2,5-difluoropyridine is used as a chemical reactant for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key intermediate in the production of drugs, contributing to the development of new medications.
Used in Advanced Organic Synthesis:
4-Chloro-2,5-difluoropyridine is used as a building block in advanced organic synthesis, where its reactivity and the presence of fluorine and chlorine atoms enable the creation of complex molecules with potential applications in various fields.
Used in Production of Other Chemicals:
4-Chloro-2,5-difluoropyridine is used as a precursor in the production of other chemicals, highlighting its versatility in the chemical industry and its role in creating a wide range of products.

InChI:InChI=1/C5H2ClF2N/c6-3-1-5(8)9-2-4(3)7/h1-2H

Upstream product

• 84476-99-3 2,5-difluoropyridine 

Downstream Products

• 169749-88-6 2-(4-chloro-5-fluoro-3-methyl-2-pyridinyl)-2-cyclopropylacetaldehyde 
• 169749-89-7 8-chloro-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid ethyl ester 
• 1620690-81-4 C₁₉H₂₁F₂N₃O₂ 

Relevant academic research and scientific papers

8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester and preparation method thereof

The invention provides a preparation method of 8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester. The preparation method comprises the following steps: step one, enabling 2, 5-difluoropyridine and chlorine supply compound to react in a non-protonic solvent, and obtaining 4-chloro-2, 5-difluoropyridine; step two, enabling 4-chloro-2, 5-difluoropyridine and methyl donor to react in a non-protonic solvent, and obtaining 4-chloro-2, 5-difluoro-3-methylpyridine; step three, enabling 4-chloro-2, 5-difluoro-3-methylpyridine and cyclopropyl acetonitrile to react under the effect of strong base, and obtaining 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropylacetonitrile; step four, preparing 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropyl acetaldehyde; step five, enabling 2-(4-chloro-5-fluorine-3-methylpyridine-2-base)-2-cyclopropyl acetaldehyde and malonic ester to react, and obtaining 8-chloro-1-cyclopropyl-7-fluorine-9-methyl-4-oxygen-4-hydrogen-quinolizine-3-carboxylic ester. The method can reduce the synthesis steps of final products, and reduce the preparation cost.