85141-94-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a building block for the synthesis of various pharmaceutical compounds. The PEG linker enhances the solubility and stability of the resulting compounds, while the bromide group facilitates the attachment of other functional groups or molecules through nucleophilic substitution reactions.
Used in Drug Delivery Systems:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG linker can be used to attach drugs or other functional groups to the terminal hydroxyl group, enabling targeted delivery and controlled release of the active ingredients.
Used in Bioconjugation:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as a bioconjugation agent to attach biomolecules, such as proteins, peptides, or nucleic acids, to various surfaces or other molecules. The PEG linker provides steric stabilization and reduces non-specific interactions, while the bromide group allows for efficient coupling through nucleophilic substitution reactions.
Used in Chemical Synthesis:
Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]is used as an intermediate in the synthesis of various organic compounds. The PEG linker can be used to control the reactivity and selectivity of the reaction, while the bromide group and terminal hydroxyl group provide versatile points for further functionalization and derivatization.

Upstream product

• 126491-78-9 12-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12-tetraoxa-1-dodecanol 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 112-60-7 Tetraethylene glycol 
• 75-21-8 oxirane 
• 81764-55-8 2-bromo<1,1,2,2-2H4>ethanol 

Downstream Products

• 10108-25-5 tetraethylene glycol monooleate 
• 1417220-90-6 methyl 2-diazo-2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 1417220-99-5 methyl 2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 1417220-97-3 tert-butyl 4-(2-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)ethyl)piperazine-1-carboxylate 
• 90952-27-5 2-(2-(2-(2-mercaptoethoxy)ethoxy)ethoxy)ethan-1-ol 

Relevant academic research and scientific papers

Monothiols derived from glycols as agents for stabilizing gold colloids in water: Synthesis, self-assembly and use as crystallization templates

Tetraethylene glycol (HO-(C2H4O)4-H) can be monofunctionalized by replacing one of the terminal hydroxy groups with the thiol SH group. The resulting molecule can be self-assembled on gold (111) surfaces. More importantly, this molecule allows the simple one-step preparation of protected, water-soluble gold colloids within a single aqueous phase. Attempts are made to use such protected water-soluble colloids as nucleating 'seeds' around which calcium carbonate can be crystallized.

Laterally functionalized pillar[5]arene: A new building block for covalent self-assembly

Laterally functionalized pillar[5]arenes were synthesized for the first time by bromination at the methylene bridge of dimethoxypillar[5]arene. The synthesized molecule was then used as a novel building block by being covalently self-assembled into polymer nanocapsules and 2D polymer films.

Complex compound

PROBLEM TO BE SOLVED: To provide a new complex compound that can be used as a catalyst for an organic synthesis reaction and in particular a surfactant type catalyst having both functions of catalytic ability and surface active ability. SOLUTION: A complex compound comprises a nitrogen-containing heterocyclic carbene ligand represented by formula (A) and including at least one metal atom selected from palladium, silver, rhodium, iridium, and ruthenium as a central metal. (R1 represents a divalent hydrocarbon group that has 2-20 carbon atoms and may include at least one atom selected from N, O, S and halogen atoms; R2 represents a hydrocarbon group having 6-70 carbon atoms and including a polyoxyalkylene group and/or a polyglyceryl group having a polymerization number of 2-20 or a hydrocarbon group having 2-20 carbon atoms and including at least one ionic functional group selected from a sulfonic acid group, a carboxyl group, an ammonium group, or their salts; and R3 represents a hydrocarbon group having 2-20 carbon atoms) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT

A Simple, effective boron-halide ethoxylation catalyst

Boron esters B(OR)3, readily derived from boric acid and alcohols, combine with iodide or bromide to catalyze the ethoxylation of alcohols and phenols, giving good rates and narrow product distributions. The combined action of a weak electrophile [B(OR)3] and a weak nucleophile (halide) allows for the ethoxylation of base-sensitive alcohols. Experiment suggests a new mechanism for this commercially important reaction proceeding through key β-haloalkoxy intermediates.

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems

A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex. The Royal Society of Chemistry 2008.

SYNTHESIS AND PROPERTIES OF CROWNSULFONYL-CONTAINING GLYCOLS

The crownsulfonates of glycols were obtained from the chlorosulfonyl derivatives of benzo-15-crown-5 and benzo-18-crown-6-ethers and glycols.The intramolecular complex formation between the peripheral hydroxyl group and the oxygen atoms of the macrocycle