Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-

Base Information

• Chemical Name: Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-
• CAS No.: 85141-94-2
• Molecular Formula: C8H17BrO4
• Molecular Weight: 257.125
• European Community (EC) Number: 886-530-0
• Mol file: 85141-94-2.mol

Synonyms:12-bromo-3,6,9,12-tetraoxadodecan-1-ol;2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]-ethanol;

Chemical Property of Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-

Chemical Property:

• Boiling Point: 321.7±27.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• PSA: 47.92000
• Density: 1.350±0.06 g/cm3(Predicted)
• LogP: 0.42340
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 256.03102
• Heavy Atom Count: 13
• Complexity: 92.2

Purity/Quality:

97% ^*data from raw suppliers

2-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COCCOCCOCCBr)O
• Description: Bromo-PEG4-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Technology Process of Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-

There total 4 articles about Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

12-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12-tetraoxa-1-dodecanol (126491-78-9) → 2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethan-1-ol (85141-94-2)

Guidance literature:

With lithium bromide; In acetone; for 5h; Heating;

Reference yield: 84.0%

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) → 2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethan-1-ol (85141-94-2)

Guidance literature:

With lithium bromide; In acetone; at 75 ℃; for 5h;

Reference yield: 64.0%

Tetraethylene glycol (112-60-7) → 2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethan-1-ol (85141-94-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1039/c7cc04778a

upstream raw materials:

12-<4'-(benzo-15-crown-5)sulfonyl>-3,6,9,12-tetraoxa-1-dodecanol

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

Tetraethylene glycol

oxirane

Downstream raw materials:

tetraethylene glycol monooleate

methyl 2-diazo-2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate

methyl 2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate

tert-butyl 4-(2-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)ethyl)piperazine-1-carboxylate