85142-34-3

Upstream product

• 201230-82-2 carbon monoxide 
• 106-95-6 allyl bromide 
• 100-61-8 N-methylaniline 
• 107-05-1 3-chloroprop-1-ene 

Downstream Products

• 1357195-42-6 (-)-4-hydroxy-N,3-dimethyl-N-phenylbutanamide 
• 134750-58-6 5-hydroxy-N-methyl-N-phenylpentanamide 
• 1393475-23-4 C₁₂H₁₅NO₂ 
• 1393475-16-5 C₁₂H₁₅NO₂ 

Relevant academic research and scientific papers

One-pot amide synthesis from allyl or benzyl halides and amines by Pd-catalysed carbonylation

Amides can be prepared from allyl or benzyl halides and primary or secondary amines, using Pd(0) catalyst under CO pressure, in a one-pot synthesis. The reaction proceeds through the acyl palladium halide formation which undergoes an acylic nucleophilic substitution from the amine.

Carbamoylation using the CO-containing Copper Complex derived from Lithium N-methylanilide

Lithium N-methylanilide, prepared from N-methylaniline and n-butyllithium, readily absorbed CO at atmospheric pressure in the presence of cuprous iodide to produce a CO-containing copper complex.Treatment of this complex with organic halides gave the corresponding amides in good yields.Keywords - carbonylation; carbamoylation; carbon monoxide; cuprous iodide; lithium N-methylanilide