851589-98-5

Upstream product

• 5930-93-8 4-nitropyrrole-2-carboxylic acid 

Downstream Products

• 851590-22-2 N-{4-[N-benzyl-N-(t-butoxycarbonyl)amino]-1-methylpyrrole-2-carbonyl}pyrrolidine 
• 851590-15-3 N-[4-(2-nitrophenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 851590-03-9 [1-methyl-4-(4-nitro-phenylamino)-1H-pyrrol-2-yl]-pyrrolidin-1-yl-methanone 
• 851590-19-7 [4-(3,5-dimethyl-phenylamino)-1-methyl-1H-pyrrol-2-yl]-pyrrolidin-1-yl-methanone 
• 851590-04-0 N-[4-(4-cyanophenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 

Relevant academic research and scientific papers

Novel non-steroidal/non-anilide type androgen antagonists: Discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands

We designed and synthesized novel pyrrole-2-carboxamide derivatives as androgen antagonists. Compounds 10 and 13 bearing benzylamine or aniline at the 4-position of the pyrrole ring showed moderate androgen antagonistic activity, and inhibited the androgen-dependent growth of Shionogi carcinoma cells (SC-3). Study of the structure-activity relationships of compound 13 led to a potent androgen antagonist 36, which has higher affinity than flutamide (4) for androgen nuclear receptor (AR). Thus, pyrrole-2-carboxamide is a new scaffold for developing AR antagonists.