851590-04-0

Basic information

• Product Name: Pyrrolidine, 1-[[4-[(4-cyanophenyl)amino]-1-methyl-1H-pyrrol-2-yl]carbonyl]-
• CAS NO: 851590-04-0
• Molecular Formula: C17H18N4O
• Molecular Weight: 294.356
• Mol File: 851590-04-0.mol

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[[4-[(4-cyanophenyl)amino]-1-methyl-1H-pyrrol-2-yl]carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[[4-[(4-cyanophenyl)amino]-1-methyl-1H-pyrrol-2-yl]carbonyl]-(851590-04-0)
• EPA Substance Registry System: Pyrrolidine, 1-[[4-[(4-cyanophenyl)amino]-1-methyl-1H-pyrrol-2-yl]carbonyl]-(851590-04-0)

Safety Data

• Hazardous Substances Data: 851590-04-0(Hazardous Substances Data)

Upstream product

• 28494-49-7 4-nitropyrrole-2-carboxylic acid chloride 
• 5930-92-7 Ethyl 4-nitropyrrole-2-carboxylate 
• 5930-93-8 4-nitropyrrole-2-carboxylic acid 
• 851589-99-6 N-(1-methyl-4-nitropyrrole-2-carbonyl)pyrrolidine 
• 851589-98-5 N-(4-nitropyrrole-2-carbonyl)pyrrolidine 
• 851590-00-6 N-(1-methyl-4-aminopyrrole-2-carbonyl)pyrrolidine 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 1058178-44-1 C₂₄H₂₄N₄O 

Relevant articles and documents

4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor

Various 4-(anilino)pyrrole-2-carboxamides were designed and synthesized as novel androgen receptor (AR) antagonists without steroidal or anilide structure, based on our strategy for developing full antagonists of nuclear receptors. Introduction of a bulky

Novel non-steroidal/non-anilide type androgen antagonists: Discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands

We designed and synthesized novel pyrrole-2-carboxamide derivatives as androgen antagonists. Compounds 10 and 13 bearing benzylamine or aniline at the 4-position of the pyrrole ring showed moderate androgen antagonistic activity, and inhibited the androgen-dependent growth of Shionogi carcinoma cells (SC-3). Study of the structure-activity relationships of compound 13 led to a potent androgen antagonist 36, which has higher affinity than flutamide (4) for androgen nuclear receptor (AR). Thus, pyrrole-2-carboxamide is a new scaffold for developing AR antagonists.