851590-00-6

Basic information

• Product Name: Pyrrolidine, 1-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-
• CAS NO: 851590-00-6
• Molecular Formula: C10H15N3O
• Molecular Weight: 193.249
• Mol File: 851590-00-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-(851590-00-6)
• EPA Substance Registry System: Pyrrolidine, 1-[(4-amino-1-methyl-1H-pyrrol-2-yl)carbonyl]-(851590-00-6)

Safety Data

• Hazardous Substances Data: 851590-00-6(Hazardous Substances Data)

Upstream product

• 5930-93-8 4-nitropyrrole-2-carboxylic acid 

Downstream Products

• 1058178-36-1 N-[4-(4-acetylphenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 1058178-31-6 N-[4-(4-nitro-3-trifluoromethylphenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 1058178-34-9 N-[4-(4-trifluoromethylphenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 1058178-38-3 N-[4-(4-methoxycarbonylphenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 851590-22-2 N-{4-[N-benzyl-N-(t-butoxycarbonyl)amino]-1-methylpyrrole-2-carbonyl}pyrrolidine 
• 851590-03-9 [1-methyl-4-(4-nitro-phenylamino)-1H-pyrrol-2-yl]-pyrrolidin-1-yl-methanone 
• 851590-15-3 N-[4-(2-nitrophenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 851590-04-0 N-[4-(4-cyanophenylamino)-1-methylpyrrole-2-carbonyl]pyrrolidine 
• 851590-19-7 [4-(3,5-dimethyl-phenylamino)-1-methyl-1H-pyrrol-2-yl]-pyrrolidin-1-yl-methanone 

Relevant articles and documents

Novel non-steroidal/non-anilide type androgen antagonists: Discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligands

We designed and synthesized novel pyrrole-2-carboxamide derivatives as androgen antagonists. Compounds 10 and 13 bearing benzylamine or aniline at the 4-position of the pyrrole ring showed moderate androgen antagonistic activity, and inhibited the androgen-dependent growth of Shionogi carcinoma cells (SC-3). Study of the structure-activity relationships of compound 13 led to a potent androgen antagonist 36, which has higher affinity than flutamide (4) for androgen nuclear receptor (AR). Thus, pyrrole-2-carboxamide is a new scaffold for developing AR antagonists.