851598-99-7Relevant academic research and scientific papers
Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors
Kitas, Eric A.,Galley, Guido,Jakob-Roetne, Roland,Flohr, Alexander,Wostl, Wolfgang,Mauser, Harald,Alker, Andre M.,Czech, Christian,Ozmen, Laurence,David-Pierson, Pascale,Reinhardt, Dieter,Jacobsen, Helmut
, p. 304 - 308 (2008/04/07)
A hydroxamic acid screening hit 1 was elaborated to 5,5-dimethyl-2-oxoazepane derivatives exhibiting low nanomolar inhibition of γ-secretase, a key proteolytic enzyme involved in Alzheimer's disease. Early ADME data showed a high metabolic clearance for t
Amino-caprolactam derivatives as γ-secretase inhibitors
Parker, Michael F.,Bronson, Joanne J.,Barten, Donna M.,Corsa, Jason A.,Du, Wengsheng,Felsenstein, Kevin M.,Guss, Valerie L.,Izzarelli, Darcy,Loo, Alice,McElhone, Kate E.,Marcin, Larry R.,Padmanabha, Ramesh,Pak, Roger,Polson, Craig T.,Toyn, Jeremy H.,Varma, Sam,Wang, Jian,Wong, Victoria,Zheng, Ming,Roberts, Susan B.
, p. 5790 - 5795 (2008/03/13)
A series of amino-caprolactam sulfonamides were developed from a screening hit. Compounds with good in vitro and in vivo γ-secretase activity are reported.
Sulfonamides
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Page/Page column 41, (2010/02/15)
The invention relates to compounds of the general formula in which R1, R2, R3, R4, R2′, R3′, R4′, R5, and X is —CHR— are as defined in the specification. The invention also provides pharmac
N-SUBSTITUTED BENZENE SULFONAMIDES
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Page/Page column 105, (2008/06/13)
Disclosed are N-substituted benzenesulfonamides for use intreating in treating or preventing cognitive disorders, such as Alzheimer′s Disease. Formula (I) In formula (I), R1, R2, R3, R4, R3’, R10
