85160-90-3

Usage

Structure

Ethyl ester derivative of 1H-indole-3-carboxylic acid

Bromomethyl group

A bromine atom attached to a carbon atom with a single bond

Methoxy group

An oxygen atom bonded to a methyl group (CH3) with a single bond

Phenylsulfonyl group

A phenyl ring (a six-carbon ring with alternating single and double bonds) connected to a sulfonyl group (SO2) with a single bond

Potential applications

Organic synthesis and medicinal chemistry

Need for further research

To explore specific properties and potential uses in various fields

Upstream product

• 80191-95-3 Ethyl 1-benzenesulphonyl-5-methoxy-2-methylindole-3-carboxylate 

Downstream Products

• 143582-27-8 ethyl 1-phenylsulfonyl-5-methoxy-2-phenylsulfonylmethylindole-3-carboxylate 
• 101458-55-3 1-Benzenesulfonyl-2-diethylaminomethyl-5-methoxy-1H-indole-3-carboxylic acid ethyl ester 
• 1158786-14-1 ethyl 2-(cyanomethyl)-5-methoxy-1-(phenylsulfonyl)-1H-indole-3-carboxylate 
• 80191-95-3 Ethyl 1-benzenesulphonyl-5-methoxy-2-methylindole-3-carboxylate 
• 85160-95-8 2-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-5-methoxy-1H-indole-3-carboxylic acid ethyl ester 
• 85160-98-1 2-[2-(3,4-Dimethoxy-phenyl)-ethyl]-5-methoxy-1H-indole-3-carboxylic acid ethyl ester 
• 89441-89-4 Ethyl 2-benzenesulfonylmethyl-5-methoxyindole-3-carboxylate 
• 143582-34-7 1-Benzenesulfonyl-2-(1-benzenesulfonyl-2-phenyl-ethyl)-5-methoxy-1H-indole-3-carboxylic acid ethyl ester 
• 143582-33-6 1-Benzenesulfonyl-2-(1-benzenesulfonyl-propyl)-5-methoxy-1H-indole-3-carboxylic acid ethyl ester 
• 143582-36-9 5-Methoxy-2-phenethyl-1H-indole-3-carboxylic acid ethyl ester 
• 34572-31-1 ethyl 5-methoxy-2-methyl-1H-indole-3-carboxylate 
• 147848-06-4 1-(9-Benzenesulfonyl-4,6-dimethoxy-9H-carbazol-3-yl)-ethanone 
• 147848-07-5 9-Benzenesulfonyl-4,6-dimethoxy-9H-carbazole-3-carbonitrile 
• 147848-03-1 4-hydroxy-6-methoxy-9-phenylsulfonylcarbazol-3-yl methyl ketone 

Relevant academic research and scientific papers

Stille carbonylation of N-protected bromomethylindoles

A variety of N-protected indolylmethylbromides are carbonylated using 5 mol % Pd(PPh3)2Cl2 under Stille conditions in the presence of an alcohol to afford the corresponding methyl/ethyl esters.

Synthesis of di-, tri-, and tetra-substituted carbazole analogs involving annulation methodology

Synthesis of substituted carbazole analogs was achieved via Michael addition followed by intramolecular cyclization and subsequent aromatization.

Unusual dimerization of N-protected bromomethylindoles/benzyl bromide with arylmetal halides: generation of indolylmethyl/benzyl radical

A detailed study on the interaction of N-protected bromomethylindoles with various types of aryl/alkyl Grignard is reported. Full experimental details on the mechanism of the unusual dimerization reaction are presented.

Synthesis of N-protected indolaldehydes using modified Hass procedure

A detailed study on oxidation of N-protected bromomethylindoles into the respective aldehydes was carried out. Using a modified Hass procedure, synthesis of aryl-/hetero-aryl aldehydes in particular indolaldehydes is achieved in reasonable yields.

A facile preparation of N-protected indolaldehydes using a modified Hass procedure

The preparation of a variety of N-protected indolaldehydes is reported via the reaction of N-protected bromomethylindoles with 2-nitropropane using NaH/DMF.

An efficient preparation of 1-phenylsulfonylindolyl methyl sulfoxides using KF/m-CPBA

A variety of 1-phenylsulfonylindolylmethyl sulfides are selectively oxidized to the corresponding sulfoxides using a hitherto unexplored KF/m-CPBA system. A major advantage is the absence of over-oxidation.