851645-64-2

Upstream product

• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 500719-87-9 4,4,4-trifluoro-1-(N-methoxy-N-methylamino)-1-phenyl-1-(trimethylsiloxyl)-2-butyne 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 62-53-3 aniline 
• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 
• 6048-29-9 triphenylphenacylphosphonium bromide 

Downstream Products

• 1392505-53-1 4,4,4-trifluoro-1-phenyl-3-(4-(trifluoromethyl)phenyl)butan-1-one 

Relevant academic research and scientific papers

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom econom

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: Mechanistic evidence for an enantiospecific pathway

Transfer news: A synthetic approach to chiral β-CF3- substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF3-bearing allylic alcohols by an intramol

Reactions of novel trifluoromethyl propargylic carbocation with carbon nucleophiles

Trifluoromethyl propargylic carbocation [I] generated from the reaction of 1-amino substituted 3-trifluoromethyl-2-propynyl trimethylsilyl ether 1 with TMSOTf in CH2Cl2 at -15 °C, followed by warming to room temperature reacted with

New approaches to β-trifluoromethylated enone derivatives

β-Trifluoromethylated enaminones 1 were prepared stereospecifically or high stercoselectively in 31-92% yields from the reaction of Weinreb amides with trifluoropropynyl lithium, followed by quenching with H2O in the presence of amine derivativ