851681-89-5 Usage
Uses
Used in Pharmaceutical Industry:
BML-288 is used as a research tool for studying the role of PDE2 in various biological processes and diseases. Its high potency and selectivity make it a valuable compound for investigating the therapeutic potential of PDE2 inhibition in treating various conditions.
Used in Drug Development:
BML-288 is used as a lead compound in the development of new drugs targeting PDE2. Its selectivity and potency make it a promising candidate for the treatment of diseases where PDE2 inhibition may be beneficial, such as inflammatory and neurodegenerative disorders.
Used in Research Applications:
BML-288 is used as a research reagent to study the molecular mechanisms of PDE2 and its role in cellular signaling pathways. This can help researchers gain a better understanding of the enzyme's function and its potential as a therapeutic target.
Check Digit Verification of cas no
The CAS Registry Mumber 851681-89-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,6,8 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 851681-89:
(8*8)+(7*5)+(6*1)+(5*6)+(4*8)+(3*1)+(2*8)+(1*9)=195
195 % 10 = 5
So 851681-89-5 is a valid CAS Registry Number.
851681-89-5Relevant academic research and scientific papers
A new chemical tool for exploring the physiological function of the PDE2 isozyme
Chambers, Robert J.,Abrams, Kristin,Garceau, Norman Y.,Kamath, Ajith V.,Manley, Christopher M.,Lilley, Susan C.,Otte, Douglas A.,Scott, Dennis O.,Sheils, Alissa L.,Tess, David A.,Vellekoop, A. Samuel,Zhang, Yan,Lam, Kelvin T.
, p. 307 - 310 (2007/10/03)
Oxindole (2) is a potent and selective PDE2 inhibitor with a favorable ADME, physiochemical and pharmacokinetic profile to allow for use as a chemical tool in elucidating the physiological role of PDE2.
OXINDOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE TYPE 2 INHIBITORS
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Page/Page column 19, (2008/06/13)
The present invention provides compounds, methods and kits for treatment of disease states or disorders mediated by PDE2. Oxindole derivatives are provided which have therapeutic use and as PDE2 inhibitors.
