851728-99-9

Upstream product

• 784193-07-3 4-(4-chlorophenyl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester lithium salt 
• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 98-86-2 acetophenone 

Downstream Products

• 876405-96-8 5-(4-chloro-phenyl)-1-(2-chloro-phenyl)-1H-pyrazole-3-carboxylic acid benzyl-(2,2-diethoxy-ethyl)-amide 
• 784193-16-4 7-chloro-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-pyrazolo[3,4-c]pyridine 
• 784193-17-5 3-(4-chloro-phenyl)-2-(2-chloro-phenyl)-2,6-dihydro-pyrazolo[3,4-c]pyridin-7-one 
• 784192-16-1 6-benzyl-2-(2-chlorophenyl)-3-(4-chlorophenyl)-2H-pyrazolo[3,4-c]pyridin-7(6H)-one 
• 851729-00-5 1-(2-chlorophenyl)-5-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid 
• 851729-03-8 acetic acid 3-[(2-chloroethyl)-(2,2-difluoropropyl)-carbamoyl]-1-(2-chlorophenyl)-5-(4-chlorophenyl)-1H-pyrazol-4-yl-ester 

Relevant academic research and scientific papers

Structure–activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease

We report the discovery of a novel series of 1,5-bisphenylpyrazoles as potent MALT1 inhibitors. Structure–activity relationship exploration of a hit compound led to a potent MALT1 inhibitor. Compound 33 showed strong activity against MALT1 (IC50/sub

Process for Preparing Bicyclic Pyrazolyl

A process for preparing compounds of Formula (I) is described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of disease linked to the mediation of the cannabinoid receptors in animals.

New bicyclic cannabinoid receptor-1 (CB1-R) antagonists

A series of conformationally constrained bicyclic derivatives derived from SR141716 was prepared and evaluated as hCB1-R antagonists and inverse agonists. Optimization of the structure-activity relationships around the 2,6-dihydro-pyrazolo[4,3-

Bicyclic pyrazolyl and imidazolyl compounds and uses thereof

Compounds of Formula (I) are described herein. The compounds have been shown to act as cannabinoid receptor ligands and are therefore useful in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals.