851847-62-6

Basic information

• Product Name: 1-cyclopropyl-4-Piperidinol
• Synonyms: 1-Cyclopropylpiperidin-4-ol;1-cyclopropyl-4-Piperidinol
• CAS NO: 851847-62-6
• Molecular Formula: C8H15NO
• Molecular Weight: 141.2108
• Mol File: 851847-62-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-cyclopropyl-4-Piperidinol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclopropyl-4-Piperidinol(851847-62-6)
• EPA Substance Registry System: 1-cyclopropyl-4-Piperidinol(851847-62-6)

Safety Data

• Hazardous Substances Data: 851847-62-6(Hazardous Substances Data)

Usage

General Description

1-Cyclopropyl-4-Piperidinol is a chemical compound with the molecular formula C8H15NO. It is a derivative of piperidine with a cyclopropyl group attached to the nitrogen atom. 1-cyclopropyl-4-Piperidinol is used as a pharmaceutical intermediate in the synthesis of various drugs and medications. It is a colorless, clear liquid that is soluble in water and has a mild, characteristic odor. 1-Cyclopropyl-4-Piperidinol is known for its role in the production of antipsychotic and anti-anxiety medications, as well as in the development of new pharmaceutical compounds. It is important for its contribution to the field of medicinal chemistry and drug discovery.

Upstream product

• 62813-01-8 1-cyclopropylpiperidin-4-one 
• 41661-47-6 piperidin-4-one 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Relevant articles and documents

Compounds with antiviral and bacteriostatic activity

The invention discloses a structural design and a synthesis method of compounds with antiviral and bacteriostatic activity. The invention particularly relates to a series of compounds which are obtained by taking piperidine pyrazole boric acid as a main body structure and performing structural modification on the piperidine pyrazole boric acid, so that the compounds become chemical synthetic drugswith the potential of being developed into antibacterial agents or antiviral drugs. The patent content comprises a synthetic route and a synthetic method of the compounds designed for the structure.

5-Hydroxyindole-2-carboxylic acid amides: Novel histamine-3 receptor inverse agonists for the treatment of obesity

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the histamine 3 receptor (H3R) in the regulation of food intake and body weight and the potential therapeutic effect of H3R inverse agonists. A pharmacophore model, based on public information and validated by previous investigations, was used to design several potential scaffolds. Out of these scaffolds, the 5-hydroxyindole-2-carboxylic acid amide appeared to be of great potential as a novel series of H3R inverse agonist. Extensive structure-activity relationships revealed the interconnectivity of microsomal clearance and hERG (human ether-a-go-go-related gene) affinity with lipophilicity, artificial membrane permeation, and basicity. This effort led to the identification of compounds reversing the (R)-R-methylhistamine-induced water intake increase in Wistar rats and, further, reducing food intake in diet-induced obese Sprague-Dawley rats. Of these, the biochemical, pharmacokinetic, and pharmacodynamic characteristics of (4,4-difluoropiperidin- 1-yl)[1-isopropyl-5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl]-methanone 36 are detailed.

TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I), wherein X1a, X1 to X5, Ra, Rb, n and R have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.