851916-81-9

Basic information

• Product Name: N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide
• Synonyms: N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide
• CAS NO: 851916-81-9
• Molecular Weight: 402.16
• Mol File: 851916-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide(851916-81-9)
• EPA Substance Registry System: N-[6-(2,6-dichloro-benzoyl)-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide(851916-81-9)

Safety Data

• Hazardous Substances Data: 851916-81-9(Hazardous Substances Data)

Upstream product

• 209971-49-3 2,2,2-trifluoro-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)acetamide 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 20511-12-0 2-amino-5-iodopyridine 
• 209971-43-7 N-(5-iodopyridin-2-yl)-4-methylbenzenesulfonamide 
• 504413-28-9 N-{6-[(2,6-dichloro-phenyl)-hydroxy-methyl]-imidazo[1,2-a]pyridin-2-yl}-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases

Structure-based design approach was successfully used to guide the evolution of imidazopyridine scaffold yielding new structural class of highly selective inhibitors of cyclin dependent kinases that were able to form a new interaction with an identified residue of the protein, Lys89. Compounds from this series have shown no detectable effect when tested against a representative set of other serine/threonine kinases such as GSK3β, CAMKII, PKA, PKC-α,β,ε,γ. Compound 2i inhibits proliferation in HCT 116 cells in tissue culture. Synthesis, co-crystal structure of CDK2 in complex with compound 2i, and preliminary SAR study are disclosed.