852051-10-6

Basic information

• Product Name: (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE
• Synonyms: (R)-Benzyl 2-methyl-4-oxopiperidine-1-carboxylate;benzyl (2R)-2-methyl-4-oxopiperidine-1-carboxylate;(R)-2-Methyl-4-oxo-piperidine-1-carboxylic acid benzyl ester;(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE
• CAS NO: 852051-10-6
• Molecular Formula: C14H17NO3
• Molecular Weight: 247.28968
• EINECS: -0
• Mol File: 852051-10-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 388.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• PKA: -1.57±0.40(Predicted)
• CAS DataBase Reference: (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE(852051-10-6)
• EPA Substance Registry System: (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE(852051-10-6)

Safety Data

• Hazardous Substances Data: 852051-10-6(Hazardous Substances Data)

Usage

Description

(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE is a piperidinone derivative with the molecular formula C13H17NO3. It is a white solid chemical compound used as an intermediate in the synthesis of various pharmaceutical drugs and organic compounds. Its molecular weight is 235.28 g/mol, and its chemical structure and properties make it suitable for use in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE is used as an intermediate in the synthesis of various medications and chemicals. Its chemical structure and properties make it a valuable component in the development of new pharmaceutical compounds.
Used in Chemical Industry:
(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE is used as a building block in the production of various organic compounds. Its versatility and reactivity in chemical reactions contribute to the creation of a wide range of chemical products.

Upstream product

• 544-97-8 dimethyl zinc(II) 
• 185847-84-1 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 
• 849928-34-3 benzyl 2-methyl-4-oxopiperidine-1-carboxylate 
• 190906-91-3 3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester 
• 620-08-6 4-methoxypyridine 
• 75-24-1 trimethylaluminum 
• 501-53-1 benzyl chloroformate 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 921599-74-8 benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate 
• 1193782-31-8 benzyl (7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide 

Relevant articles and documents

Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors

General methods to prepare chiral N-heterocyclic molecular scaffolds are greatly sought after because of their significance in medicinal chemistry. Described here is the first general catalytic methodology to access a wide variety of chiral 2- and 4-substituted tetrahydro-quinolones, dihydro-4-pyridones, and piperidones with excellent yields and enantioselectivities, utilizing a single catalyst system.

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

The IC50 of a beta-secretase (BACE-1) lead compound was improved ～200-fold from 11 μM to 55 nM through the addition of a single methyl group. Computational chemistry, small molecule NMR, and protein crystallography capabilities were used to com

HEPATITIS B ANTIVIRAL AGENTS

The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.