(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE

Base Information

• Chemical Name: (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE
• CAS No.: 852051-10-6
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 852051-10-6.mol

Synonyms:(R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE;(R)-Benzyl 2-methyl-4-oxopiperidine-1-carboxylate;benzyl (2R)-2-methyl-4-oxopiperidine-1-carboxylate;(R)-2-Methyl-4-oxo-piperidine-1-carboxylic acid benzyl ester

Chemical Property of (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE

Chemical Property:

• Boiling Point: 388.1±42.0 °C(Predicted)
• PKA: -1.57±0.40(Predicted)
• PSA: 0.00000
• Density: 1.164±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99%, ^*data from raw suppliers

(R)-1-Cbz-2-Methylpiperidin-4-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE

There total 17 articles about (R)-1-CBZ-2-METHYL-PIPERIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl 2-methyl-4-oxopiperidine-1-carboxylate (849928-34-3,852051-10-6) → benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate (921599-74-8,852051-10-6)

Guidance literature:

With Chiralpak AD; In methanol;

Reference yield: 95.0%

methylmagnesium bromide (75-16-1) + benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (185847-84-1) → benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate (921599-74-8,852051-10-6)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; (R,R)-1,2-bis(2,5-diphenylphospholanyl)ethane; In dichloromethane; at -78 ℃; for 12h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201906237

Reference yield: 84.0%

3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester (190906-91-3) → benzyl 2-methyl-4-oxopiperidine-1-carboxylate (849928-34-3,852051-10-6)

Guidance literature:

With acetic acid; zinc; at 100 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.06.082

upstream raw materials:

dimethyl zinc(II)

benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate

benzyl 2-methyl-4-oxopiperidine-1-carboxylate

3,4-dihydro-2-methyl-4-oxo-1(2H)-pyridinecarboxylic acid phenylmethyl ester

Downstream raw materials:

benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

benzyl (7S)-1-(3-fluorophenyl)-7-methyl-2-thia-1,3,8-triazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

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