852065-86-2Relevant academic research and scientific papers
PdII-catalyzed stereospecific formation of tetrahydro- and 3,6-dihydro[2H]pyran rings: 1,3-Chirality transfer by intramolecular oxypalladation reaction
Uenishi, Jun'ichi,Ohmi, Masashi,Ueda, Atsushi
, p. 1299 - 1303 (2005)
The stereospecific synthesis of 2,6-disubstituted tetrahydropyran and 3,6-dihydro[2H]pyran is described. The PdII-catalyzed cyclization of the hydroxy nucleophile to the allylic alcohol takes place efficiently under mild conditions, with the st
A chemoenzymatic asymmetric synthesis of methyl (6S,13R)-6,13-dihydroxytetradeca-(2E,4E,8E)-trienoate, a component of Mycosphaerella rubella
Sharma, Anubha,Gamre, Sunita,Chattopadhyay, Subrata
experimental part, p. 1164 - 1167 (2009/09/30)
The first asymmetric synthesis of (6S,13R)-6,13-dihydroxytetradeca-(2E,4E,8E)-trienoate has been developed. The key steps of the synthesis were the use of an efficient lipase-catalyzed acylation, a chiral template-driven enantiocontrolled allylation for introducing the stereogenic centers, and a cross-metathesis for controlling the C-8 olefin geometry.
