85209-06-9Relevant articles and documents
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo
Vesci, Loredana,Milazzo, Ferdinando Maria,Stasi, Maria Antonietta,Pace, Silvia,Manera, Francesco,Tallarico, Carlo,Cini, Elena,Petricci, Elena,Manetti, Fabrizio,De Santis, Rita,Giannini, Giuseppe
, p. 368 - 379 (2018/08/17)
Small series of acylguanidine and acylthiourea derivatives were synthesized in gram-scale and assayed for their ability to modulate the Hh signalling pathway. In vitro studies showed a low micromolar inhibitory activity toward tumor cell lines, while the oral administration revealed an excellent ADME profile in vivo. Compound 5 emerged as the most active and safe inhibitor of colon cancer cells both in vitro and in a xenograft mouse model. Based on these data, 5 could be prioritized to further development with the perspective of clinical studies.
Solvent- and light-controlled unidirectional transit of a nonsymmetric molecular axle through a nonsymmetric molecular wheel
Arduini, Arturo,Bussolati, Rocco,Credi, Alberto,Monaco, Simone,Secchi, Andrea,Silvi, Serena,Venturi, Margherita
, p. 16203 - 16213 (2013/02/23)
The development of a pseudorotaxane motif capable of performing unidirectional threading and dethreading processes under control of external stimuli is particularly important for the construction of processive linear motors based on rotaxanes and, at leas
SELECTIVE REACTIONS OF α-ARYL WITTIG REAGENTS WITH THE FORMYL MOIETY OF 4-FORMYLBENZOYL CHLORIDE
Waetjen, Frank,Dahl, Otto,Buchardt, Ole
, p. 4741 - 4744 (2007/10/02)
The benzylic Wittig reagents 2a, 2b and 2e react with 4-formylbenzoyl chloride 1 to give 40-60percent yields of products 3 derived from selective attack at the formyl group of 1; The same selectivity is not found for the non-stabilized ylids 2c and 2d or
