85210-61-3Relevant academic research and scientific papers
Synthesis method of alpha-acylamino ketone compound
-
Paragraph 0027-0029; 0030-0032; 0064, (2020/12/08)
The invention discloses a synthesis method of an alpha-acylamino ketone compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixingan alkenyl azide compound 1, a carboxylic acid compound 2 and an organic solvent, and heating to react to obtain the alpha-acylamino ketone compound 3. Compared with the prior art, the method has thefollowing advantages: (1) the synthesis process is simple and efficient, no catalyst is needed in the whole process, and the alpha-acylamino ketone compound can be obtained with high yield by dissolving the alkenyl azide compound and the carboxylic acid compound in the solvent and stirring; (2) raw materials are cheap and easy to obtain, reaction conditions are mild, and operation is simple; (3) the substrate is wide in application range and can be used for modifying drug molecules; and (4) the atom economy is high, and the requirements of green chemistry are met.
Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions
Gao, Cai,Zhou, Qianting,Yang, Li,Zhang, Xinying,Fan, Xuesen
, p. 13710 - 13720 (2020/11/13)
An efficient synthesis of α-amidoketone derivatives through the cascade reactions of carboxylic acids with vinyl azides is presented. Compared with literature protocols, notable features of this new method include catalyst-free conditions, broad substrate scope, good tolerance of a wide range of functional groups, and high efficiency. In addition, the synthetic potential of this method as a tool for late-stage modification was convincingly manifested by its application in the structural elaborations of a number of carboxylic acid drug molecules.
Synthesis and hypolipidemic activities of 5-thienyl-4-oxazoleacetic acid derivatives
Moriya,Takabe,Maeda,Matsumoto,Takashima,Takeyama
, p. 333 - 341 (2007/10/02)
A series of 2,5-disubstituted 4-oxazoleacetic acid derivatives was synthesized and evaluated for hypolipidemic activity. Among them, those with a thienyl group at C-5 of the oxazole ring exerted highly potent hypolipidemic effects in rats. 2-(4-Fluorophen
Thienyloxazolylacetic acid derivatives and process for preparing
-
, (2008/06/13)
A compound of the formula STR1 wherein Ring A is phenyl or halogenophenyl and R1 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof and processes for preparing the same are disclosed. Said compound is useful as a hypolipidemic agent.
