852159-30-9

Upstream product

• 75-52-5 nitromethane 
• 104-88-1 4-chlorobenzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 

Downstream Products

• 1007346-14-6 (1R,2S,3R,4R,5S)-3-(4-chlorophenyl)-5-isopropyl-2,4-dinitrocyclohexanol 
• 114703-75-2 2-(4-chlorophenyl)propane-1,3-diamine 

Relevant academic research and scientific papers

Deep eutectic solvent as solvent and catalyst: One-pot synthesis of 1,3-dinitropropanes: Via tandem Henry reaction/Michael addition

The Henry reaction was performed using microwave heating within the deep eutectic solvent (DES) choline chloride/urea (ChCl/urea) which acted as both the catalyst and solvent for the reaction. The optimisation of the conditions (temperature, heating mode,

Synthesis of 3-Nitroisoxazoles via Copper Acetate-Mediated Reaction of Benzaldehydes with Nitromethane

A copper acetate-mediated reaction of benzaldehydes with nitromethane to synthesis of 3-nitroisoxazoles is reported. A variety of nitro-aryl-disubstituted isoxazole derivatives can be prepared in moderate to good yields with benign functional group tolera

Base-catalyzed reactions enhanced by solid acids: Amine-catalyzed nitroaldol (Henry) reactions enhanced by silica gel or mesoporous silica SBA-15

The reactions of various aldehydes with CH3NO2 catalyzed by Et3N, n-C6H13NH2, and Me2N(CH2)2NH2 were accelerated by the addition of silica gel to give aromatic (aliphatic) β-nitroalcohols, aromatic nitroalkenes, and aromatic 1,3-dinitroalkanes, respectively. Mesoporous silica SBA-15 showed higher activity than silica gel for the synthesis of aromatic nitroalkenes by the reactions of the corresponding aldehydes with CH3NO2 catalyzed by n-C6H13NH2.

Unexpected reactivity of graphene oxide with DBU and DMF

An unusual reaction between GO, DBU and DMF, that typically uses base and solvent, has been thoroughly analyzed providing valuable basic knowledge about the reactivity of GO, which is essential to control functionalization and therefore the properties of

Michael addition at neutral pH: A facile synthesis of 1,3-dinitroalkanes

Base-catalyzed Michael addition of nitroalkane to conjugated nitroalkene suffers serious practical difficulties due to the formation of oligomeric byproduct. Given its importance for synthesis of pharmacologically relevant organic compounds, a scalable synthesis of 1,3-dinitroalkane is developed by addition of nitroalkane to nitroalkene in aqueous phosphate buffer at pH 7.0 with no added traditional base catalyst.

One-pot synthesis of 1 ,3-dinitroalkanes catalysed by nickel species

The reaction of aromatic aldehydes with nitromethane afforded a one-pot preparation of 1,3-dinitroalkanes in the presence of a nickel catalytic system. This efficient and simple method proceeded with moderate to high yields (56-99%) under mild conditions.

KINASE INHIBITORS

The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

Enantioselective desymmetrization of prochiral 1,3-dinitropropanes via organocatalytic allylic alkylation

An enantioselective desymmetrization of prochiral 1,3-dinitropropanes has been developed which proceeds via enantiogroup differentiating organocatalytic allylic alkylation. Densely functionalized products with two vicinal stereocenters were obtained gener

Silica grafted polyethylenimine as heterogeneous catalyst for condensation reactions

Primary amine groups were attached to a silica surface by using α,ω-diamines derivatives and (3-glycidyloxypropyl)-trimethoxysilane activation. The same activation was used to graft polyethylenimine, which also contains secondary and tertiary amine groups. These silica aminated structures were tested as heterogeneous catalysts in nitroaldol condensation with nitromethane, the derivative with the polyethylenimine moiety being the more active catalyst. This catalyst also showed efficiency in the Knoevenagel condensation of benzaldehydes with ethyl cyanoacetate under very mild reaction conditions and showed much the same efficiency when used in consecutive reaction runs. A reaction mechanism with participation of the several amine groups of the catalysts is discussed.

Synthesis of optically active heterocyclic compounds by preparation of 1,3-dinitro derivatives and enzymatic enantioselective desymmetrization of prochiral diamines

A general approach for the highly efficient chemical preparation of novel optically active 2-substituted propane-1,3-diamines is described. Diamines have been obtained from the corresponding commercially available aldehydes in a straightforward, two-step synthesis via the corresponding 1,3-dinitro compounds, which were hydrogenated under mild reaction conditions by using platinum dioxide as the catalyst. Subsequent enzymatic enantioselective desymmetrization mediated by Pseudomonas cepacia lipase allowed the recovery of a family of monocarbamates in good to high, enantiomeric excesses (70-90% ee).