85220-97-9Relevant academic research and scientific papers
Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: Osmiumporphyrin complex/tert-butyl hydroperoxide system
Iida, Takashi,Ogawa, Shoujiro,Hosoi, Keiji,Makino, Mitsuko,Fujimoto, Yasuo,Goto, Takaaki,Mano, Nariyasu,Goto, Junichi,Hofmann, Alan F.
, p. 823 - 830 (2007)
(Chemical Equation Presented) tert-Butyl hydroperoxide catalyzed by (5,10,15,20-tetramesitylporphyrinate) osmium(II) carbonyl [Os(TMP)CO] complex was found to be a highly efficient versatile oxidant for C-H carbons in steroid substrates. When reacted with representative steroids with an estrane, pregnane, 5β-cholane, or 5α-cholestane structure, regioselective oxyfunctionalization and/or oxidative degradation occurred to give a variety of novel and uncommon derivatives in one step.
