852213-25-3

Upstream product

• 749924-31-0 (2R,5Z,8S,9R)-8-(tert-butyldiphenylsilanyloxy)-9-(tert-butyldiphenylsilanyloxymethyl)-2,3,4,7,8,9-hexahydrooxonine-2-carbaldehyde 
• 852213-23-1 (2R,5Z,8S,9R)-8-(tert-butyldiphenylsilanyloxy)-9-(tert-butyldiphenylsilanyloxymethyl)-2-vinyl-2,3,4,7,8,9-hexahydrooxonine 

Downstream Products

• 852213-27-5 (1S,3S,4R,6R,9R)-3-(tert-butyldiphenylsilanyloxy)-4,6-divinyl-5,10-dioxabicyclo[7.1.0]decane 
• 852213-26-4 (1S,3S,4R,6R,9R)-3-(tert-butyldiphenylsilanyloxy)-6-vinyl-5,10-dioxabicyclo[7.1.0]decane-4-carbaldehyde 
• 852213-20-8 (2R,5Z,8S,9R)-8-(tert-butyldiphenylsilanyloxy)-2,9-divinyl-2,3,4,7,8,9-hexahydrooxonine 
• 852213-28-6 (1R,2S,4S,6R,9R,10Z)-2-(tert-butyldiphenylsilanyloxy)-5,12-dioxatricyclo[7.2.1.0(4,6)]-dodec-10-ene 
• 852213-21-9 (1S,2S,4Z,8R,9Z)-2-(tert-butyldiphenylsilanyloxy)-11-oxabicyclo[6.2.1]undeca-4,9-diene 
• 852213-31-1 (1S,3S,4R,6R,9S)-3-(tert-butyldiphenylsilanyloxy)-4-hydroxymethyl-6-vinyl-5,10-dioxabicyclo[7.1.0]decane 
• 852213-30-0 (2R,5Z,8S,9R)-8-(tert-butyldiphenylsilanyloxy)-2-vinyl-2,3,4,7,8,9-hexahydrooxonine-9-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of simplified analogues of eleutherobin via a Claisen rearrangement/RCM strategy

The enantioselective synthesis of a number of simplified analogues of the cytotoxic natural product eleutherobin is reported.

Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy

The enantioselective synthesis of a simplified eleutherobin analogue 7 by ring closing metathesis (RCM) of the 2,9-divinyl-substituted tetrahydro-oxonin 5 is described; the analogue 7 and an advanced intermediate 15 revealed microtubule stabilising proper