85222-82-8Relevant academic research and scientific papers
Reductive formylation of isoquinoline derivatives with formamide and synthesis of 2-formyltetrahydroisoquinolines
Venkov, Atanas P.,Ivanov, Ilian I.
, p. 1433 - 1438 (2007/10/03)
Reductive formylation of isoquinoline derivatives as 3,4- dihydroisoquinolines 1, enamines and enamides of tetrahydroisoquinoline 2 and the reaction of 2-(2-acylphenyl)ethylamides 3 with formamide afforded the corresponding N-formyltetrahydroisoquinolines 4 and N- acyltetrahydroisoquinolines 5.
Synthesis of isoquinolines from 2-phenylethylamines, amides, nitriles and carboxylic acids in polyphosphoric acid
Venkov, Atanas P.,Ivanov, Ilian I.
, p. 12299 - 12308 (2007/10/03)
A convenient one pot synthesis of 1-, 1.3-substituted 3,4-dihydroisoquinolines 5 enamines 10 and 3-oxo-2,3-dihydroisoquinolines 18 as well as of enamides 22 of isoquinoline from 2-phenyl-, 1,2-diphenylethylamines, phenylacetamides, phenylacetonitriles, N-acylphenylethylamines and carboxylic acids in nonaqueous media has been accomplished.
Novel Zinc-Promoted Alkylation of Iminium Salts. New Synthesis of Benzylisoquinoline, Phthalidylisoquinoline, and Protoberberine Alkaloids and Related Compounds
Shono, Tatsuya,Hamaguchi, Hiroshi,Sasaki, Manji,Fujita, Shumei,Nagami, Kimihiko
, p. 1621 - 1628 (2007/10/02)
Zinc-promoted reductive coupling reaction of iminium salts with alkyl halides was found to be a successful key reaction for synthesis of a variety of alkaloids such as benzylisoquinoline, phthalidylisoquinoline, and protoberberine alkaloids.More specifically, laudanosine, cordrastine, hydrastine, narcotine, tetrahydropalmatine, and canadine were obtained.A new route for the synthesis of the emetine and yohimbine skeletons was exploited.
