852222-46-9

Basic information

• Product Name: 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one
• CAS NO: 852222-46-9
• Molecular Weight: 283.246
• Mol File: 852222-46-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one(852222-46-9)
• EPA Substance Registry System: 4-amino-8-(4-nitro-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one(852222-46-9)

Safety Data

• Hazardous Substances Data: 852222-46-9(Hazardous Substances Data)

Upstream product

• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 98651-70-8 2-amino-4-methoxypyridine-3-carbonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 306960-30-5 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one 

Downstream Products

• 852222-48-1 4-amino-8-(4-amino-phenyl)-8H-pyrido[2,3-d]pyrimidin-5-one 

Relevant articles and documents

Pyridopyrimidinones

The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and X′ have the designations cited in patent claim 1. Said c

4-AMINO-5-OXO-8-PHENYL-5H-PYRIDO-[2,3-D]-PYRIMIDINE DERIVATIVES AS TYROSINE KINASE AND RAF KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS

Compounds of formula (I), where R6, R7, R8,R9,Het1, X and X' have the meanings given in claim 1 are tyrosine kinase inhibitors, in particular, of TIE-2, and Raf kinases and can be used, amongst other things, for the treatment of tumours.

PYRIDOPYRIMIDINONES

The invention relates to compounds of formula (I) wherein R1, R2 , R3 , R4 , R5, R6 , R7 , R8, R9, X and X' have the designations cited in patent claim 1. Said compounds are inhibitors of tyrosine kinases, especially TIE-2, and Raf kinases, and can, inter alia, be used for the treatment of tumours.