85225-11-2Relevant academic research and scientific papers
An efficient synthesis of fenoprofen, an important antiinflammatory agent
Sonawane, H. R.,Nanjundiah, B. S.,Nazeruddin, G. M.
, p. 705 - 706 (2007/10/02)
A simple and practical synthesis of (+/-)-fenoprofen, a well-known non-steroidal antiinflammatory agent, from the commercially available m-phenoxybenzaldehyde has been described.
Manufacture of alpha-arylalkanoic acids and precursors
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, (2008/06/13)
α-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an α-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the α-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding α-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding α-arylalkanoic acid.
