852305-07-8

Upstream product

• 117340-79-1 2-bromo-1-(4-methoxyphenyl)ethanol 
• 75-64-9 tert-butylamine 
• 1256291-74-3 2-(tert-butylimino)(4'-methoxyphenyl)ethanone 
• 1190369-16-4 (-)-(S)-2-(n-butylthio)-1-(p-methoxyphenyl)-ethanol 
• 1190369-18-6 (n-butyl)[(2S)-2-hydroxy-2-(p-methoxyphenyl)-ethyl](methyl)sulfonium iodide 
• 1190369-10-8 n-butyl (2S)-2-hydroxy-2-(p-methoxyphenyl)-ethyl (R)-sulfoxide 
• 119072-55-8 tert-butylisonitrile 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 852305-09-0 3-{tert-butyl[(2S)-2-hydroxy-2-(4-methoxyphenyl)ethyl]amino}propanenitrile 

Relevant academic research and scientific papers

Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction

We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2-amino-1-arylethanols, a structural motif commonly encountered in the family of β-adrenergic blockers or agonists, through a Lewis base-catalyzed SiClsub

Asymmetric synthesis of β-amino alcohols by the transfer hydrogenation of α-keto imines

The asymmetric transfer hydrogenation of representative aryl and benzofuranyl 2-tert-butylaminoethanones with formic acid-triethylamine, catalyzed by RhCl[(R,R)-TsDPEN](C5Me5), produced the corresponding β-tert-butylamino alcohols in 97-99% ee. A short asymmetric synthesis of (R)-bufuralol, a potent β-adrenergic receptor antagonist, is described. This approach to β-amino alcohols from ketones circumvents the halogenation-reduction-amination sequence.

Enantioselective synthesis of phenyl-ethanolamines through application of chiral sulfoxide

Efficient enantioselective synthesis of (R)- and (S)-enantiomers of 2-(tert-butylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol. Copyright Taylor & Francis Group, LLC.

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3- carboxylic acid

(Chemical Equation Presented) A practical asymmetric synthesis of N-tert-butyl disubstituted pyrrolidines via a nitrile anion cyclization strategy is described. The five-step chromatography-free synthesis of (3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrr