85236-51-7

Upstream product

• 103-90-2 4-acetaminophenol 
• 100-02-7 4-nitro-phenol 
• 121836-29-1 4-nitro-2,6-bis(pyrrolidin-1'-ylmethyl)phenol 
• 81079-95-0 3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyacetanilide 

Downstream Products

• 5201-88-7 4-<3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyanilino>-7-chloroquinoline 
• 129210-19-1 2,6-bis(pyrrolidin-1'-ylmethyl)-4-(7''-trifluoromethylquinazolin-4''-ylamino)phenol 
• 343935-64-8 4-Chloro-N-[3,5-bis(1-pyrrolidinomethyl)-4-hydroxyphenyl]benzenesulfonamide 
• 95257-88-8 4-<3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyanilino>-7-(trifluoromethyl)quinoline 
• 130291-24-6 2,6-bis(pyrrolidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 

Relevant academic research and scientific papers

Microwave-induced Mannich reaction - Synthesis of some Mannich derivatives of p-aminophenol

Mono and bis substituted dialkylamino alkyl-p-aminophenol 3 are prepared by treating paracetamol 1 with formaldehyde and appropriate secondary amines followed by deacetylation using 6 M HCI in unmodified domestic microwave oven in unsealed borosil vessels

Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility

The present invention relates to new compounds of the formula STR1 wherein X is STR2 wherein R1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is hydrogen or hydroxy; (Y)A is positioned ortho to W and is an aminoloweralkyl having the formula --CH2 NR2 R3 where R2 and R3 are the same or different and may be lower alkyl or R2 and R3 may together with N form a pyrrolidine, piperidine or azepine ring, and A is 2; n and m are independently from 0 to 5; and R is straight or branched C1 -C10 alkyl, straight or branched C3 -C10 cycloalkyl, straight or branched C2 -C4 alkenyl or straight or branched C2 -C4 alkynyl, or a pharmaceutically acceptable salt thereof. These compounds are useful in the treatment of various cardiac arrhythmias.

Potential Antimalarials. VII. Di-Mannich Bases of 4-aminophenol via 4-Nitrophenols

A series of di-Mannich bases have been prepared from 4-nitrophenol and paraformaldehyde with dimethylamine, diethylamine, dipropylamine, N-(2'-hydroxyethyl)methylamine, piperidine, 3- and 4-methylpiperidine, 3,5-dimethylpiperidine or pyrrolidine.These nit

Phthalazine compounds, compositions and use

The present invention relates to new compounds of the formula STR1 alkylene, or --S-- where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)A is --CH2 NR2/s

Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 1. Heteroarylamine Derivatives

Twenty-four structural derivatives of the antiarrhythmic drug changrolin were synthesized and tested for antiarrhythmic and parasympatholytic activities.It was found that while the bis(pyrrolidinylmethyl)phenol pattern of changrolin appeared to be optimal