852383-82-5

Basic information

• Product Name: ethyl (R)-8-chloro-6-hydroxyoctanoate
• Synonyms: ethyl (R)-8-chloro-6-hydroxyoctanoate
• CAS NO: 852383-82-5
• Molecular Weight: 222.712
• Mol File: 852383-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (R)-8-chloro-6-hydroxyoctanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (R)-8-chloro-6-hydroxyoctanoate(852383-82-5)
• EPA Substance Registry System: ethyl (R)-8-chloro-6-hydroxyoctanoate(852383-82-5)

Safety Data

• Hazardous Substances Data: 852383-82-5(Hazardous Substances Data)

Upstream product

• 105-38-4 vinyl propionate 
• 1070-65-1 6-hydroxy-8-chlorooctanoic acid ethyl ester 
• 123-20-6 vinyl n-butyrate 
• 108-05-4 vinyl acetate 

Downstream Products

• 1200-22-2 (R)-1,2-dithiolane-3-pentanoic acid 

Relevant articles and documents

Enzymatic resolution of a chiral chlorohydrin precursor for (R)-α-lipoic acid synthesis via lipase catalyzed enantioselective transacylation with vinyl acetate

A new and efficient process was developed by lipase-catalyzed transacylation to resolve ethyl 8-chloro-6-hydroxy octanoate (ECHO) to produce an important chiral precursor for the synthesis of (R)-α-lipoic acid. After optimization of biocatalyst, solvent, acyl donor, temperature and enzyme loading, (S)-O-acetylated ECHO was achieved in 94% ee, 35% isolated yield and 38 g L-1 d-1 space-time yield using Novozym 435 as biocatalyst. Subsequently, the enzymatic resolution reaction was successfully repeated for 7 batches, retaining over 40% conversions.