852391-45-8

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
7-Bromo-DL-tryptophan is used as a research compound for exploring its biological activities, such as antimicrobial, anticancer, and antioxidant properties. Its unique structure with the bromo substituent allows for the investigation of its potential therapeutic effects and mechanisms of action.
Used in Drug Development:
7-Bromo-DL-tryptophan is utilized as a lead compound in drug development, where its pharmacological and physiological properties can be optimized for specific therapeutic applications. The bromo substitution may enhance its efficacy and selectivity, making it a promising candidate for the treatment of various diseases.
Used as a Precursor in Chemical Synthesis:
7-Bromo-DL-tryptophan is employed as a chemical intermediate and precursor in the synthesis of other bioactive compounds. Its unique structure can be further modified or used as a building block to create novel molecules with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 75816-18-1 N-acetyl-7'-bromo-DL-tryptophan 
• 51417-51-7 7-bromo-1H-indole 
• 852391-42-5 2-(7-Bromo-1H-indol-3-ylmethyl)-2-formylamino-malonic acid diethyl ester 
• 852391-39-0 (7-bromo-1H-indol-3-yl)-N,N-dimethylmethanamine 

Downstream Products

• 732983-21-0 (+/-)-7-bromotryptophan methyl ester 
• 75816-19-2 (S)-7-bromo-tryptophan 
• 496929-99-8 7'-bromo-D-tryptophan 
• 1219432-58-2 C₁₆H₁₉BrN₂O₄ 
• 1598418-85-9 C₂₁H₂₀BrN₃O₃ 
• 1598418-66-6 C₂₂H₂₂BrN₃O₃ 
• 1598418-65-5 C₂₂H₂₂BrN₃O₃ 

Relevant academic research and scientific papers

Total synthesis of ent-(-)-azonazine using a biomimetic direct oxidative cyclization and structural reassignment of natural product

A biomimetic approach has been investigated and developed for the total synthesis of azonazine, an unusual marine natural cyclopeptide containing a rigid transannular 10-membered ring. A hypervalent iodine-mediated direct oxidative cyclization was success

Structure-activity relationship study of novel necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.

Inhibitors of cellular necrosis

The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.