732983-21-0 Usage
Uses
Used in Chemical and Biochemical Research:
(+/-)-7-bromotryptophan methyl ester is utilized as a building block for the synthesis of various bioactive molecules and pharmaceuticals. Its distinctive structure and properties make it a valuable tool for investigating and developing new compounds with potential therapeutic applications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (+/-)-7-bromotryptophan methyl ester is employed as a key intermediate in the synthesis of drugs targeting specific biological pathways. Its unique chemical features allow for the creation of novel therapeutic agents with improved efficacy and selectivity.
Used in Analytical Chemistry:
(+/-)-7-bromotryptophan methyl ester serves as a reference compound in analytical chemistry for the development and validation of methods to separate and identify enantiomers. This is crucial for understanding the different biological activities and potential side effects of each enantiomer.
Used in Neuropharmacology:
In neuropharmacology, (+/-)-7-bromotryptophan methyl ester is used as a research tool to study the role of tryptophan and its derivatives in the central nervous system. This helps in the development of drugs targeting neurological disorders and modulating neurotransmission.
Used in Peptide Synthesis:
(+/-)-7-bromotryptophan methyl ester is employed in the synthesis of peptides with specific biological activities. Its incorporation into peptide sequences allows for the creation of novel bioactive peptides with potential applications in medicine and biotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 732983-21-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,2,9,8 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 732983-21:
(8*7)+(7*3)+(6*2)+(5*9)+(4*8)+(3*3)+(2*2)+(1*1)=180
180 % 10 = 0
So 732983-21-0 is a valid CAS Registry Number.
732983-21-0Relevant academic research and scientific papers
Structure-activity relationship study of novel necroptosis inhibitors
Teng, Xin,Degterev, Alexei,Jagtap, Prakash,Xing, Xuechao,Choi, Sungwoon,Denu, Regine,Yuan, Junying,Cuny, Gregory D.
, p. 5039 - 5044 (2007/10/03)
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-α. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). A SAR study revealed that several positions of the indole were intolerant of substitution, while small substituents at the 7-position resulted in increased inhibitory activity. The hydantoin ring was also quite sensitive to structural modifications. A representative member of this compound class demonstrated moderate pharmacokinetic characteristics and readily entered the central nervous system upon intravenous administration.
