852402-86-9

Basic information

• Product Name: (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide
• Synonyms: (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide
• CAS NO: 852402-86-9
• Molecular Weight: 310.396
• Mol File: 852402-86-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide(852402-86-9)
• EPA Substance Registry System: (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide(852402-86-9)

Safety Data

• Hazardous Substances Data: 852402-86-9(Hazardous Substances Data)

Upstream product

• 852402-76-7 (S)-8-methoxyquinoline-2-carboxylic acid (1-phenylethyl)amide 
• 3033-80-5 8-methoxy-2-methylquinoline 
• 103854-64-4 8-methoxy-2-quinolinecarboxaldehyde 
• 21141-35-5 8-methoxyquinoline-2-carboxylic acid 

Downstream Products

• 852402-97-2 (4aS,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-1-one 
• 852403-07-7 (4aS,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline 

Relevant articles and documents

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands

We report the design and synthesis of a series of enantiomerically pure hexahydropyrazinoquinolines as potent and selective ligands for the dopamine 3 subtype receptor using a newly developed synthetic method and using in vitro pharmacological evaluation. Our efforts yielded optically pure ligands with high affinities for the D3 receptor and outstanding selectivity over closely related D1-like and D2-like receptors. For example, compound 38a has a Ki value of 5.7 nM to the D3 receptor and selectivity greater than 10000- and 1600-fold over the D 1-like and D2-like receptors, respectively, and thus is one of the most selective D3 ligands reported to date.