21141-35-5

Basic information

• Product Name: 8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID
• Synonyms: 8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID;8-methoxy-2-Quinolinecarboxylic acid
• CAS NO: 21141-35-5
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19406
• Mol File: 21141-35-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 385.421°C at 760 mmHg
• Flash Point: 186.896°C
• Appearance: /
• Density: 1.325g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: 2-8°C
• PKA: 3.72±0.30(Predicted)
• CAS DataBase Reference: 8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID(21141-35-5)
• EPA Substance Registry System: 8-METHOXY-QUINOLINE-2-CARBOXYLIC ACID(21141-35-5)

Safety Data

• Hazardous Substances Data: 21141-35-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 923, 1984 DOI: 10.1016/S0040-4039(01)80063-0

InChI:InChI=1/C11H9NO3/c1-15-9-4-2-3-7-5-6-8(11(13)14)12-10(7)9/h2-6H,1H3,(H,13,14)

Upstream product

• 92735-81-4 8-methoxyquinoline-2-carbonitrile 
• 3033-80-5 8-methoxy-2-methylquinoline 
• 78224-47-2 methyl 8-methoxyquinoline-2-carboxylate 
• 1571-30-8 8-hydroxy-quinoline-2-carboxylic acid 
• 88-75-5 2-hydroxynitrobenzene 
• 6759-78-0 8-hydroxyquinoline-2-carbonitrile 
• 6686-05-1 C₁₀H₁₀NO₂⁽¹⁺⁾*CH₃O₄S^(1-) 
• 1127-45-3 8-Hydroxyquinoline-N-oxide 
• 826-81-3 2-methyl-8-quinolinol 
• 103854-64-4 8-methoxy-2-quinolinecarboxaldehyde 
• 70127-96-7 2-amino-3-methoxy-benzaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 110-86-1 pyridine 
• 78224-64-3 (E)-8-methoxy-2-styrylquinoline 

Downstream Products

• 1571-30-8 8-hydroxy-quinoline-2-carboxylic acid 
• 852402-97-2 (4aS,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-1-one 
• 852402-92-7 (4aR,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-1-one 
• 852403-07-7 (4aS,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline 
• 852403-02-2 (4aR,1'S)-10-methoxy-3-(1-phenylethyl)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline 
• 852402-81-4 (2R,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide 
• 852402-86-9 (2S,3'S)-8-methoxy-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (1-phenylethyl)amide 
• 852402-76-7 (S)-8-methoxyquinoline-2-carboxylic acid (1-phenylethyl)amide 

Relevant articles and documents

The regiospecific total synthesis of lavendamycin methyl ester

-

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands

We report the design and synthesis of a series of enantiomerically pure hexahydropyrazinoquinolines as potent and selective ligands for the dopamine 3 subtype receptor using a newly developed synthetic method and using in vitro pharmacological evaluation. Our efforts yielded optically pure ligands with high affinities for the D3 receptor and outstanding selectivity over closely related D1-like and D2-like receptors. For example, compound 38a has a Ki value of 5.7 nM to the D3 receptor and selectivity greater than 10000- and 1600-fold over the D 1-like and D2-like receptors, respectively, and thus is one of the most selective D3 ligands reported to date.

Preparation and characterization of Langmuir-Blodgett films of N-hexadecyl-8-hydroxy-2-quinolinecarboxamide and its lanthanum complex

A new amphiphilic ligand, N-hexadecyl-8-hydroxy-2-quinolinecarboxamide (HHQ), and its lanthanum complex La(HHQ)2, were synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy. The characteristics of the monolayer, Langmuir-Blodgett (LB) films and cast films of HHQ and La(HHQ)2 were investigated by different physical methods, including surface pressure-area isotherms, absorption and fluorescence spectra and low-angle X-ray diffraction analysis. The LB film of La(HHQ)2 has good vertical homogeneity and the in-plane conductivity parallel to the compression direction is found to be 3.85 × 10-5 Sm-1.