852619-81-9Relevant academic research and scientific papers
Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors
Chen, Bin,Petukhov, Pavel A.,Jung, Mira,Velena, Alfredo,Eliseeva, Elena,Dritschilo, Anatoly,Kozikowski, Alan P.
, p. 1389 - 1392 (2007/10/03)
A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better
Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors
Anandan, Sampath-Kumar,Ward, John S.,Brokx, Richard D.,Bray, Mark R.,Patel, Dinesh V.,Xiao, Xiao-Xi
, p. 1969 - 1972 (2007/10/03)
Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into the hydroxamic acid based SAHA (1) scaffold in order to identify non-hydroxamate compounds as potential inhibitors of histone deacetylases. Two sets of mercaptoamides 2 and 3 with varying spacer length were synthesized and their HDAC inhibitory activity was evaluated. Low micromolar inhibition was observed for mercaptoamides 2e, 3b, and 3d.
