852631-24-4

Upstream product

• 101-55-3 4-Bromodiphenyl ether 
• 31221-06-4 5-diazo-pyrimidine-2,4,6-trione 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 54916-27-7 1-(4-(4-bromophenoxy)phenyl)ethan-1-one 
• 106-41-2 4-bromo-phenol 
• 852631-06-2 2-[4-(4-bromophenoxy)phenyl]-1-morpholin-4-yl-ethanethione 
• 852631-15-3 [4-(4-bromophenoxy)phenyl]malonic acid dimethyl ester 
• 852631-10-8 [4-(4-bromophenoxy)phenyl]acetic acid methyl ester 
• 852631-08-4 [4-(4-bromophenoxy)phenyl]acetic acid 
• 852631-19-7 5-[4-(4-bromophenoxy)phenyl]barbituric acid 

Downstream Products

• 393796-64-0 5-[4-(4-bromo-phenoxy)-phenyl]-5-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione 
• 681287-20-7 5-[4-(4-bromo-phenoxy)-phenyl]-5-piperazin-1-yl-pyrimidine-2,4,6-trione 
• 681287-35-4 5-[4-(4-bromo-phenoxy)-phenyl]-5-[4-(4-trimethylsilanyl-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione 

Relevant academic research and scientific papers

Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds

A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free N-H groups are tolerated on the barbituric acid, with no complications arising from N-H insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.

C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging

Studies have demonstrated a positive correlation between inflammation, metastasis, or atherosclerosis and the unbalanced or culminated expression of matrix metalloproteinases (MMPs). The molecular imaging of locally upregulated MMP activity in vivo is a c