852671-03-5Relevant academic research and scientific papers
Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors
Patel, Hitesh K.,Grotzfeld, Robert M.,Lai, Andiliy G.,Mehta, Shamal A.,Milanov, Zdravko V.,Chao, Qi,Sprankle, Kelly G.,Carter, Todd A.,Velasco, Anne Marie,Fabian, Miles A.,James, Joyce,Treiber, Daniel K.,Lockhart, David J.,Zarrinkar, Patrick P.,Bhagwat, Shripad S.
, p. 5182 - 5185 (2009)
A series of diaryl ureas with an amide substitution at the 4-position was prepared and found to be potent and selective FLT3 inhibitors with good oral bioavailability and efficacy in a tumor xenograft model.
