85272-30-6 Usage
Uses
Used in Pharmaceutical and Biochemical Research:
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) is used as a silylating agent for the preparation of diisopropylsilyl-linked oligonucleotide analogs. This application is crucial in the development of novel therapeutic agents and diagnostic tools in the pharmaceutical and biochemical research industries.
Used in Organic Synthesis:
In the field of organic synthesis, DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) is used as a reagent for the silylation of 5'-O-(dimethoxytrityl)-2'-deoxynucleosides. This process results in the formation of 3'-O-diisopropylsilanols, which are key intermediates in the synthesis of various nucleoside derivatives.
Used in Nucleic Acid Chemistry:
DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) is used as a coupling agent in the formation of 3',5'-linked dinucleosides and trinucleosides selectively. This selective coupling is essential for the synthesis of specific oligonucleotide sequences, which have potential applications in molecular biology and medicine.
Used in the Synthesis of Oligonucleotide Analogs:
In the synthesis of oligonucleotide analogs, DIISOPROPYLSILYL BIS(TRIFLUOROMETHANESULFONATE) is used as a key component in the preparation of tetrathymidylate oligomers. This application is vital for the development of new therapeutic agents and diagnostic tools in the field of molecular biology.
Preparation
conveniently prepared by the slow addition
of 2 equiv of trifluoromethanesulfonic acid to a stirring mixture
of chlorodiisopropylsilane, followed by direct distillation of the
product from the reaction flask to yield the product as a pale
yellow oil.
Check Digit Verification of cas no
The CAS Registry Mumber 85272-30-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,2,7 and 2 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 85272-30:
(7*8)+(6*5)+(5*2)+(4*7)+(3*2)+(2*3)+(1*0)=136
136 % 10 = 6
So 85272-30-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H14F6O6S2Si/c1-5(2)23(6(3)4,19-21(15,16)7(9,10)11)20-22(17,18)8(12,13)14/h5-6H,1-4H3
85272-30-6Relevant academic research and scientific papers
Procatalyst Composition with Silyl Glutarate and Method
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Page/Page column 11, (2010/11/03)
Disclosed are procatalyst compositions having an internal electron donor which includes a silyl glutarate and optionally an electron donor component. Ziegler-Natta catalyst compositions containing the present procatalyst compositions exhibit strong activity and produce propylene-based olefins with high isotacticity.
DIISOPROPYLSILYL DITRIFLATE AND DI-tert-BUTYLSILYL DITRIFLATE: NEW REAGENTS FOR THE PROTECTION OF DIOLS
Corey, E. J.,Hopkins, Paul B.
, p. 4871 - 4874 (2007/10/02)
Diisopropylsilyl ditriflate and di-tert-butylsilyl ditriflate, each available from the appropriate dialkylchlorosilane and triflic acid, react with 1,2-, 1,3-, and 1,4-diols usually at 25 deg C in the presence of 2,6-lutidine to provide the corresponding dialkylsilylene derivatives in high yield.These derivatives, which are readily deprotected under mild conditions, can be utilized for selective reactions of polyhydroxy compounds.
