852836-61-4Relevant articles and documents
Synthesis and biological evaluation of 14-alkoxymorphinans. 22. Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities
Lattanzi, Roberta,Spetea, Mariana,Schüllner, Falko,Rief, Silvia B.,Krassnig, Roland,Negri, Lucia,Schmidhammer, Helmut
, p. 3372 - 3378 (2007/10/03)
Novel 14-alkoxy-substituted (e.g. allyloxy, benzyloxy, naphthylmethoxy) morphinan-6-one derivatives were synthesized and biologically evaluated. Compounds 6-9 and 11 displayed affinities in the subnanomolar range to μ opioid receptors which were comparabl