3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Base Information

Chemical Name:3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)
CAS No.:852836-61-4
Molecular Formula:C₂₆H₂₉NO₅
Molecular Weight:435.52
Hs Code.:

Synonyms:3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

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Chemical Property of 3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

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Technology Process of 3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

There total 2 articles about 3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 100-39-0
benzyl bromide

: 263713-08-2
4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

: 852836-61-4
3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 42h;
DOI:10.1021/jm040894o

Reference yield:

: 76-41-5
oxymorphone

: 852836-61-4
3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / methanesulfonic acid / 24 h / Heating

2: 42 percent / potassium carbonate / dimethylformamide / 42 h / 85 °C

With methanesulfonic acid; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm040894o

Reference yield: 71.0%

: 852836-61-4
3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane)

: 74-88-4
methyl iodide

: 1417541-04-8
(4R,4aS,7aR,12bS)-9-(benzyloxy)-4a-methoxy-3-methyl-1,2,3,4,4a,5,6,7a-octahydrospiro[4,12-methanobenzofuro[3,2-e]isoquinoline-7,2'-[1,3]dioxolane]

Guidance literature:: 3-benzyloxy-4,5α-epoxy-14-hydroxy-17-methylmorphinan-6-spiro-2'-(1,3-dioxolane); With sodium hydride; In Pionier 2076; N,N-dimethyl-formamide; for 2h; Cooling with ice;

methyl iodide; In Pionier 2076; N,N-dimethyl-formamide; at 20 ℃;