852860-46-9

Upstream product

• 922504-26-5 phenyl(1-tosylpiperidin-4-yl)methanone 
• 37586-22-4 4-benzoylpiperidine 
• 115-46-8 C₁₈H₂₁NO 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-58-3 phenylmagnesium bromide 
• 14548-46-0 4-Benzoylpyridine 
• 20735-04-0 (1,2,3,6-tetrahydro-1-methylpyridin-4-yl)diphenylmethanol 
• 6071-92-7 VUF 4589 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 112818-77-6 ethyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate 

Downstream Products

• 22940-59-6 4-benzoyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 
• 916976-33-5 4-benzhydrylidene-1-(4-methylphenylsulfonyl)-piperidine 

Relevant academic research and scientific papers

Synthesis and crystal structure of [1-(toluene-4-sulfonyl)-piperidin-4-yl]- methanol

The title compound, [1-(toluene-4-sulfonyl)-piperidin-4-yl]-methanol was synthesized by the condensation of diphenyl(piperidin-4-yl)methanol with p-toluenesulfonyl chloride in methylene dichloromethane as solvent and triethylamine as the base. The product obtained was characterized by spectroscopic techniques and the structure was investigated by X-ray crystallography. The compound crystallizes in the monoclinic crystal class in the space group P21/c with cell parameters a=10.2490(13) A, b=11.4710(9) A, c=20.997(3) A, =116.344(3), V=2212.2(5) A3 for Z=4. The structure reveals that the piperidine ring is in a chair conformation. The geometry around the S atom is comparable with the classic tetrahedral value. The structure exhibits both inter and intramolecular hydrogen bonds of the type O-HO and C-HO.

Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-n) were synthesized and characterized by 1H NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents.

CAN-mediated rearrangement of 4-benzhydrylidenepiperidines

Several 1-substituted phenyl-(4-phenylpiperidin-4-yl)methanones are synthesized in modest overall yields starting from the reaction of different 1-substituted 4-benzhydrylidenepiperidines via CAN-mediated rearrangement. This facile strategy was also used to synthesize meperidine analog.