922504-26-5

Basic information

• Product Name: Methanone, [1-[(4-methylphenyl)sulfonyl]-4-piperidinyl]phenyl-
• CAS NO: 922504-26-5
• Molecular Formula: C19H21NO3S
• Molecular Weight: 343.447
• Mol File: 922504-26-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methanone, [1-[(4-methylphenyl)sulfonyl]-4-piperidinyl]phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [1-[(4-methylphenyl)sulfonyl]-4-piperidinyl]phenyl-(922504-26-5)
• EPA Substance Registry System: Methanone, [1-[(4-methylphenyl)sulfonyl]-4-piperidinyl]phenyl-(922504-26-5)

Safety Data

• Hazardous Substances Data: 922504-26-5(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 347885-68-1 4-bromo-1-tosylpiperidine 
• 289890-80-8 4-iodo-1-[(4-methylphenyl)sulfonyl]piperidine 
• 93-97-0 benzoic acid anhydride 
• 65-85-0 benzoic acid 
• 80213-12-3 1-[(4-methylbenzene)-sulfonyl]-4-piperidinol 
• 13939-06-5 molybdenum hexacarbonyl 
• 98-80-6 phenylboronic acid 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 98-59-9 p-toluenesulfonyl chloride 
• 147636-36-0 1-[(4-methylphenyl)sulfonyl]piperidine-4-carboxylic acid 
• 582299-09-0 {1-[(4-methylphenyl)sulfonyl]piperidin-4-yl}methanol 
• 553666-09-4 1-[(4-methylphenyl)sulfonyl]piperidine-4-carbaldehyde 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 852860-46-9 diphenyl[1-(toluene-4-sulfonyl)piperidin-4-yl]methanol 
• 916976-33-5 4-benzhydrylidene-1-(4-methylphenylsulfonyl)-piperidine 
• 922504-30-1 1-(4-methylphenylsulfonyl)-5,5-diphenylazepan-4-one 
• 22940-59-6 4-benzoyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 

Relevant articles and documents

A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports the development, f

Palladium and visible-light mediated carbonylative Suzuki-Miyaura coupling of unactivated alkyl halides and aryl boronic acids

Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.

Gram-scale ketone synthesis by direct reductive coupling of alkyl iodides with acid chlorides

Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under small-scale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields. Georg Thieme Verlag Stuttgart. New York.