85287-36-1Relevant academic research and scientific papers
Synthesis of novel and photolabile philanthotoxin analogs: Glutamate receptor antagonists
Choi,Goodnow,Kalivretenos,Chiles,Fushiya,Nakanishi
, p. 4793 - 4822 (2007/10/02)
The synthetic methods for 27 novel and photolabile philanthotoxin analogs are described. Most analogs were synthesized by two general methods with modifications of these methods where necessary.
Competitive Singlet-Singlet Energy Transfer and Electron Transfer Activation of Aryl Azides: Application to Photo-Cross-Linking Experiments
Shields, Charles J.,Falvey, Daniel E.,Schuster, Gary B.,Buchardt, Ole,Nielsen, Peter E.
, p. 3501 - 3507 (2007/10/02)
Direct irradiation of 4-phenyl azide (DAA) in an inert solvent with UV light causes ring expansion to an inermediate dehydroazepine and eventual isolation of 4,4'-azobisbenzene> (AZB).The dehydroazepine can be trapped with nucleophilic reagents to give substituted 3H-azepines.The photochemistry of DAA takes a different course when it is sensitized by pyrene, 1-acetamidopyrene (5), or 9-acetamidoacridine (2).Under these conditions, single-electron transfer occurs in competition with energy transfer as evidenced by detection of radical ions in laser transient absorption spectroscopy and by formation of 4-aniline (DAH) as a major product.Energy transfer and electron transfer compete also when the sensitizer and the aryl azide are linked together by a flexible chain of methylene groups.These results have particular significance for the application of such compounds to phtolabeling experiments.
Designing Photoaffinity Labeling Reagents for Chromatin Studies
Buchardt, Ole,Ehrbar, Ulrich,Larsen, Charles,Moeller, Joergen,Nielsen, Peter E.,et al.
, p. 4123 - 4127 (2007/10/02)
The synthesis of a series of reagents for photoaffinity labeling of the proteins in chromatin is described and discussed.The reagents contain one or two DNA-intercalating groups, a photoprobe, and a fluorometrically detectable group.The syntheses were aim
