85287-97-4Relevant academic research and scientific papers
Highly Regioselective and Stereospecific Functionalization of 1,2-Proanediol with Trimethyl(X)silanes Employing the 1,3,2λ5-Dioxaphospholane Methodology
Mathieu-Pelta, Isabel,Evans, Slayton A.
, p. 3409 - 3413 (2007/10/02)
The regioselective ring opening of (S)-4-methyl-2,2,2-triphenyl-1,3,2λ5-dioxaphospholanes (2) was initiated with several trimethylsilyl reagents (Me3SiX: X = PhS, I, Br; Cl, CN, and N3) to afford the regioisomeric (silyloxy)phosphonium salts.A stereospecific extrusion of triphenylphosphine oxide from these oxyphosphonium salts gave predominatly the thermodynamically less stable C-2-X-substituted derivatives with nearly complete inversion of stereochemistry at the C-2 stereogenic center (i.e., X = PhS).
O-SILYLATED ENOLATE PHENYLTHIOALKYLATION: a SYNTHESIS OF α,β-UNSATURATED 5- AND 6-MEMBERED LACTONES.
Khan, Hassan A.,Paterson, Ian
, p. 5083 - 5084 (2007/10/02)
ZnBr2-catalysed phenylthioalkylation of keten bis(trimethylsilyl)acetals, obtained from carboxylic acids, with appropriate α-chlorosulphides can be used to prepare γ- and δ-lactones.
