852948-13-1

Usage

Uses

Used in Biochemical Research:
[14C]-MB07811 is used as a tracer for monitoring the fate of the compound in living organisms, providing valuable information about its pharmacokinetics and potential applications in drug development.
Used in Pharmaceutical Research:
[14C]-MB07811 is used as a tracer to study the compound's movement and distribution in biological systems, which aids in understanding its potential applications in drug development and safety precautions.
Used in Radiolabeling Techniques:
[14C]-MB07811 is used as a radiolabeled compound for various radiolabeling techniques in research, allowing scientists to track the compound's interactions and behavior within biological systems.
Used in Safety and Handling Procedures:
[14C]-MB07811 is used as a radioactive substance that requires appropriate safety precautions and handling procedures when working with it in research settings.
Used in Drug Development:
[14C]-MB07811 is used as a tracer in the development of new drugs, helping researchers understand the compound's pharmacokinetics and its potential for therapeutic applications.
Used in Medical Imaging:
[14C]-MB07811 is used as a radioactive tracer in medical imaging techniques, such as positron emission tomography (PET), to visualize the distribution and metabolism of the compound in the body.
Used in Environmental Studies:
[14C]-MB07811 is used as a tracer in environmental studies to track the movement and distribution of the compound in ecosystems, providing insights into its environmental impact and potential for biodegradation.

Upstream product

• 852949-11-2 3,5-dimethyl-4-[(3'-iso-propyl-4'-methoxymethoxyphenyl)-hydroxymethyl]phenol 
• 328236-45-9 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol 
• 852947-39-8 [14C]-MB07344 
• 625095-57-0 (S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol 
• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 328236-42-6 4-bromo-2-isopropyl phenyl methoxymethyl ether 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 328236-47-1 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol 
• 328236-44-8 2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde 
• 852947-40-1 diethyl [3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenoxy]methylphosphonate 
• 328236-46-0 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)-O-triisopropylsilylphenol 
• 328236-43-7 (4-bromo-3,5-dimethylphenoxy)triisopropylsilane 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 852950-33-5 cis (S)-2-[(4-(4'-acetoxy-3'-iso-propylbenzyl)-3,5-dimethylphenoxy)methyl]-4-(3-chlorophenyl)-2-oxo-2λ5-[1,3,2]-dioxaphosphonane 

Downstream Products

• 916055-26-0 cis(S)-2-[(3,5-dimethyl-4-(5'-iodo-4'-hydroxy-3'-iso-propylbenzyl)phenoxy)methyl]-4-(3-chlorophenyl)-2-oxo-2λ5-[1,3,2]-dioxaphosphonane 

Relevant academic research and scientific papers

PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND

A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.

Preparation method of cyclic phosphonate compound

The invention provides a preparation method of a cyclic phosphonate compound. The preparation method comprises the following steps: (1) reacting a compound as shown in a formula 9 with a chlorination reagent to obtain a phosphonyl chloride intermediate 11

Novel Phosphinic Acid-Containing Thyromimetics

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs

Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized to exploit the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve the therapeutic index. Nine PAs showed excellent TR binding affinities (TRβ

NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS

The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.

LEWIS ACID MEDIATED SYNTHESIS OF CYCLIC ESTERS

Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.