852949-11-2

Upstream product

• 328236-45-9 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzylhydroxy)-O-triisopropylsilylphenol 
• 26307-50-6 4-bromo-2-isopropyl-phenol 
• 328236-42-6 4-bromo-2-isopropyl phenyl methoxymethyl ether 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 328236-44-8 2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde 

Downstream Products

• 852949-12-3 diethyl [3,5-dimethyl-4-[(3'-iso-propyl-4'-methoxymethoxyphenyl)-hydroxymethyl]phenoxy]methylphosphonate 
• 852947-40-1 diethyl [3,5-dimethyl-4-(4'-methoxymethoxy-3'-iso-propylbenzyl)phenoxy]methylphosphonate 
• 852947-39-8 [14C]-MB07344 
• 852948-13-1 [14C]-MB07811 
• 328236-47-1 3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol 
• 852948-80-2 diethyl [3,5-dimethyl-4-(3'-iso-propyl-4'-methoxymethoxybenzoyl)phenoxy]methylphosphonate 
• 852949-13-4 diethyl [3,5-dimethyl-4-[(4'-hydroxy-3'-isopropylphenyl)methoxymethyl]phenoxy]methylphosphonate 

Relevant academic research and scientific papers

Preparation method of cyclic phosphonate compound

The invention provides a preparation method of a cyclic phosphonate compound. The preparation method comprises the following steps: (1) reacting a compound as shown in a formula 9 with a chlorination reagent to obtain a phosphonyl chloride intermediate 11

PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND

A method for preparing the cyclic phosphonate compound of Formula I is described. The method significantly improves the stereoselectivity of the compound with the required configuration.

Novel Phosphinic Acid-Containing Thyromimetics

The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.

NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS

The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.