853017-03-5Relevant academic research and scientific papers
A Phosphorimidate Rearrangement for the Facile and Selective Preparation of Allylic Amines
Chen, Bin,Mapp, Anna K.
, p. 5364 - 5365 (2004)
Allylic phosphorimidates, readily prepared from the combination of an allylic alcohol, an azide, and a chlorophosphite, undergo [3,3]-rearrangement under thermal conditions to provide single isomers of allylic phosphoramidates. This new rearrangement is tolerant of a range of substitution patterns on the reactants. Treatment of the products of the rearrangement with ethanethiolate followed by acid produces a protected allylic amine. This strategy thus provides an attractive and versatile procedure for the preparation of key synthetic intermediates, allylic amines. Copyright
