853018-47-0

Basic information

• Product Name: N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide
• Synonyms: N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide
• CAS NO: 853018-47-0
• Molecular Weight: 448.565
• Mol File: 853018-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide(853018-47-0)
• EPA Substance Registry System: N-ethyl-6-methoxy-1'-(2-phenoxyethyl)-4,9-dihydrospiro[β-carboline-1,3'-pyrrolidine]-2(3H)-carboxamide(853018-47-0)

Safety Data

• Hazardous Substances Data: 853018-47-0(Hazardous Substances Data)

Upstream product

• 66-83-1 5-methoxytryptamine hydrochloride 
• 853020-95-8 6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] 
• 853020-88-9 1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] 
• 853020-69-6 6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] 
• 109-90-0 ethyl isocyanate 

Relevant articles and documents

NOVEL BETA-CARBOLINES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR (GHSR) ANTAGONISTS

The present invention relates to compounds of Formula (I): Formula (I) wherein R-R, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.